"Jacob left Beer-sheba and headed toward Charan."
At first, Zeir Anpin, or the Cosmic Man, has immature intelligence, or "small brain." But what is Zeir Anpin? It is a spiritual entity roughly equivalent to how humanity interacts with God. The brain of Zeir Anpin is represented by the name of God - Elohim - repeated three times. The gematria of Elohim is 86, and three times that is 258, and this is exactly the gematria of Charan. Thus Jacob's going to Charan represents the progressing maturity of the Cosmic Man.
Jacob himself comes from a higher level, the Supernal Father, who is the father of Zeir Anpin. In fact, Jacob derives from the qualities of Victory, Glory, and Foundation of the Supernal Father, and this is the secret meaning of the phrase, "Jacob came out of Be'er-sheba," since Foundation is called "Be'er" - the well.
The last letters of the phrase, "And Jacob left," ו'צא 'עקב מבאר, constitute the word "Be'er," but they can also be read as אבר - organ - or foundation. Jacob leaving Be'er-sheba and going to Charan thus represents a progressive stage of the Cosmic Man's maturity, leading to his acquiring a "big brain," a process in which Jacob is instrumental.
We thus see that the physical Jacob represents spiritual changes in the world which occur through him and are hidden in him. In the same way, higher levels of spirituality hide inside lower levels and pretend that they are not there. Their relationship to the lower levels are that of the soul to the body, and in fact they are called the soul of the previous level.
Art: Eugene Delacroix - Jacob Wrestling with the Angel